Peer Reviewed Studies

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The nanoparticle catalytic efficiency in wound healing was evaluated in a diabetic animal model. The use of the nanoparticle enhanced the natural healing processes with a faster remodeling stage in the study. The biological effects of the nanoparticle were:

• Infection protection
• Enhanced natural healing in comparison with the control group
• Accelerated wound healing forming granular tissue restoring different skin layers in comparison with the control group

NanoSALV was used to treat a diabetic foot ulcer in a 58-year old male patient. The patient presented type 2 diabetes mellitus with 13 years of evolution. This patient was already scheduled for amputation. In order to avoid the amputation, the patient was included into the clinical trial and treated with NanoSALV. In this case, NanoSALV was successful at treating the diabetic foot ulcer to avoid the already prescribed amputation. After a month of treatment, the necrotic tissue of the toes disappeared presenting complete epithelialization below them. After two months of treatment, the injury in the base of the heel was completely clean and had a multiplying granulating tissue. In conclusion, NanoSALV was successful in treating the patient’s diabetic foot ulcer.

NanoSALV was used to treat a diabetic foot ulcer in a 62-year old female with several comorbidities and chonich complications of diabetes. The diabetic foot ulcer was debrided prior to NanoSALV administration. NanoSALV was applied over the ulcer every second day for 10 months. Significant improvement was observed in the wound healing process since the first applications. The infection was limited, and tissue regeneration was enhanced until complete healing of the ulcer. After 10 months, the scar was all re-modeled, without any inflammatory signs and with health skin